Huntington Disease

Huntington disease (HD) is a progressive neurodegenerative disorder for which there is currently no effective therapy, despite the causative genetic defect that underlies the disease - a mutation in the huntingtin gene - being discovered almost two decades ago. The articles in this Review Series describe some of the recent advances in understanding HD at the molecular level and highlight some of the innovative therapeutic approaches that are moving towards the clinic, offering hope for families with this devastating disease.