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Rethinking Mental Disorders

Series edited by Thomas R. Insel

Mental disorders such as schizophrenia, bipolar illness, depression, and autism are the number one source of medical disability for people 15–44 years of age in the U.S. and Canada. In the past, these disorders have been considered psychological conflicts or chemical imbalances, but, as highlighted in this Review series, recent research indicates they are brain disorders, developmental disorders, and complex genetic disorders.
Disruptive insights in psychiatry: transforming a clinical discipline
Schizophrenia from a neural circuitry perspective: advancing toward rational pharmacological therapies
Targeted electrode-based modulation of neural circuits for depression
Bipolar disorder: from genes to behavior pathways
Children with obsessive-compulsive disorder: are they just “little adults”?
The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders