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Cytokines and disease

Series edited by Marc Feldmann

Cytokines are small protein mediators involved in essentially all biological processes. As such, abnormalities in cytokines, their receptors, and the signaling pathways that they initiate are involved in a wide variety of diseases. This Review Series discusses the important role of cytokines and their receptors in just a few of these diseases, specifically three chronic inflammatory disease areas and two forms of cancer, highlighting their potential as therapeutic targets.
Many cytokines are very useful therapeutic targets in disease
Evidence that cytokines play a role in rheumatoid arthritis
The cytokine network in asthma and chronic obstructive pulmonary disease
Nuanced roles of cytokines in three major human brain disorders
Following the cytokine signaling pathway to leukemogenesis: a chronology
Signal integration: a framework for understanding the efficacy of therapeutics targeting the human EGFR family