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Epithelial-mesenchymal transition

Series edited by Raghu Kalluri

Epithelial-mesenchymal transition (EMT) describes the series of events by which adherent, polarized epithelial cells convert to a mesenchymal cell phenotype, which includes an ability to both migrate and invade the extracellular matrix. As discussed in the articles in this Review series, EMT is now a recognized mechanism for dispersing cells in embryos, forming fibroblasts/mesenchymal cells in injured tissues, and initiating invasive and metastic behavior in epithelial cancer cells.
EMT: When epithelial cells decide to become mesenchymal-like cells
The basics of epithelial-mesenchymal transition
Biomarkers for epithelial-mesenchymal transitions
Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease