Therapeutic potential of RNAi
Series edited by Alan M. Gewirtz
 | Since the discovery in 1998 that gene expression could be silenced by RNA interference (RNAi), RNAi has become a routine tool for investigating the function of individual genes and gene products in the laboratory. This Review Series highlights some of the challenges that remain to be overcome if the medicinal promise of post-transcriptional gene silencing with short-interfering RNA and other molecules capable of inducing RNAi is to be fulfilled. |
On future’s doorstep: RNA interference and the pharmacopeia of tomorrow
Alan M. Gewirtz
View article Published December 3, 2007
Chemical modification: the key to clinical application of RNA interference?
David R. Corey
View article Published December 3, 2007
Nonviral delivery of synthetic siRNAs in vivo
Saghir Akhtar , Ibrahim F. Benter
View article Published December 3, 2007
Therapeutic application of RNAi: is mRNA targeting finally ready for prime time?
Dirk Grimm, Mark A. Kay
View article Published December 3, 2007
