Home > Review series > The legacy of the Philadelphia chromosome
 

The legacy of the Philadelphia chromosome

Series edited by Gary Koretzky

In 1960, Peter C. Nowell described an unusual small chromosome present in leukocytes from patients with chronic myelogenous leukemia that was thereafter designated the Philadelphia chromosome. This Review series includes contributions from individuals who performed critical experiments in the wake of the description of the Philadelphia chromosome, reflecting the nearly 50 years of work inspired by Nowell’s initial finding.
The legacy of the Philadelphia chromosome
Discovery of the Philadelphia chromosome: a personal perspective
Treatment for chronic myelogenous leukemia: the long road to imatinib
Stem cells in prostate cancer initiation and progression
ErbB receptors: from oncogenes to targeted cancer therapies
Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications
Applying the discovery of the Philadelphia chromosome